Poly(2‐ethyl‐2‐oxazoline) grafted gellan gum for potential application in transmucosal drug delivery

Gellan gum (GG) has been used to prepare polymeric carriers with prolonged retention on the eye surface for topical ocular drug delivery. In this work, GG was chemically modified short poly(2-ethyl-2-oxazoline) (PEtOx) chains that were expected have minimal adhesion mucosal tissues (mucoadhesion). The choice of synthetic procedure, solvents, and reagents dictated by biocompatibility materials possible application in grafts synthesized via cationic ring-opening polymerization their living attached onto deprotonated gellan backbone. derivatives three degrees grafting prepared varying in-feed mass ratio PEtOx over GG. NMR FT-IR spectroscopies, thermogravimetric analysis, SEC evidenced had actually taken place. However, a greater diffusion coefficient determined copolymer, using diffusion-ordered spectroscopy (NMR), relation unmodified GG, suggested either partial degradation backbone or more compact structure copolymer. its graft copolymers (GG-g-PEtOx) found be highly biocompatible cells cultured under induction at concentration 1, 0.1 0.01 mg/mL demonstrated physiological morphology, as well an increase viability proliferation.